Tuesday, January 19, 2010

plus 4, Dulaney thinks pink - Weblogs.baltimoresun.com

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plus 4, Dulaney thinks pink - Weblogs.baltimoresun.com

Dulaney thinks pink - Weblogs.baltimoresun.com

Posted: 19 Jan 2010 11:45 AM PST

The Dulaney girls basketball team will host a "Think Pink--Go Passionately Pink for the Cure" breast cancer awareness fundraiser at Friday night's games with Franklin. All proceeds from the games -- JV at 5:30 p.m. and varsity at 7 -- will be donated to the Susan G. Komen for the Cure foundation.

Last season's event raised more than $2,400 for the Kay Yow/WBCA Cancer Fund. Kay Yow, the sister of University of Maryland athletic director Debbie Yow and the longtime women's basketball coach at North Carolina State, died last January after a long battle with breast cancer.


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Eric Brinker elected to Komen for the Cure Board - Dallas Business Journal

Posted: 19 Jan 2010 11:52 AM PST

Eric Brinker, the son of Susan G. Komen for the Cure founder Nancy Brinker, has been named to the non-profit cancer research organization's board.

Brinker is filling a board post left vacant by his father Norman Brinker, who passed away in 2009.

Brinker has been advocating for the organization since his early childhood. His mother Nancy founded the organization after the death of her sister, Susan G. Komen, who died after battling breast cancer.

Eric Brinker was elected to the board to serve a two-year term with the organization.

At the moment, Brinker is owner and president of Metro Leasing Co., in Peoria, Ill., where he operates a commercial real estate portfolio.

Brinker began his career in business waiting tables at Chili's Bar & Grill, the restaurant chain his father Norman Brinker built.

He is a graduate of Bradley University in Peoria, Ill. and trained at the University of Economics in Prague, Czech Republic.

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Halozyme, BioAlta Team Up Against Disease - San Diego Business Journal

Posted: 19 Jan 2010 12:43 PM PST

San Diego-based biotech Halozyme Therapeutics Inc. has entered into a research collaboration with contract management firm BioAlta LLC of San Diego aimed at finding potential treatments for cancer and other conditions.

Financial terms of the deal, announced Jan. 19, were not disclosed.

Halozyme stands to receive exclusive worldwide commercial rights for any treatments discovered during the initial three-year collaboration. The collaboration will focus on cancer, inflammatory diseases and dermatology.

Shares of Halozyme, traded under the symbol HALO on Nasdaq, rose about 1 percent at $5.86 in morning trading.

In October, Halozyme and pharmaceutical giant Roche began dosing patients in a Phase 3 trial testing Halozyme's Enhanze technology in a subcutaneous formulation with Roche's anticancer drug Herceptin. The technology is anticipated to allow patients with HER2-positive breast cancer to administer the drug at home by themselves.

— Heather Chambers

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Clutter-busting tips and resources - Minneapolis Star Tribune

Posted: 19 Jan 2010 12:21 PM PST

Give it up. Some think getting rid of things is wasteful. But finding good uses for them is greener than letting them molder or fall apart in your garage. The items you no longer need could be doing someone else some good. "You may have things sitting in your basement that people could really use," Wendt said.

WHERE TO TAKE IT

FOR CASH

There are a wide variety of consignment stores around the Twin Cities (check yellow-page directories for those nearest you). For furniture and household goods, one option is H&B Gallery, 2730 Hennepin Av. S., Minneapolis. The store sells secondhand furniture, antiques and art, as well as dishes, glassware and jewelry. "It doesn't have to be perfect, but it has to be in good condition," said co-owner Tony Scornavacco.

For clothing, consider Clothes Mentor (five Minnesota locations, with two more opening this spring). Unlike most consignment stores, which pay after your items sell, Clothes Mentor pays cash upfront. Clothes Mentor is selective, accepting only current styles (two years old or newer) and items in excellent condition. "It's more about style than about brand," said Chad Olson, chief operating officer. "We take designers like Ann Taylor, but we'll also take Target and Kohl brands if it's in style." Clothes Mentor also deals in accessories, such as purses, shoes and jewelry. And items that don't meet their standards can be left for charitable donation. (www.clothesmentor.com)

FOR DONATION

Some charities accept donated furniture, but many do not, and those that do often have particular requirements. One option is Bridging (www.bridging.org), which serves families in transition by giving them items to set up a household. Bridging accepts furniture and housewares, such as cookware, linens and dishes. Dressers and kitchen tables/chairs are especially needed, said Mary Proepper, manager, external relations. Bridging doesn't have a repair facility, so items should be intact and in good condition, but age and style aren't important. Bridging has two warehouse locations, Bloomington and Roseville, and items can be dropped off without an appointment, 10 a.m.-6 p.m. Mon.-Thu., and 9 a.m.-3 p.m. Fri.-Sat. Residential pickup, for a fee, also is available.

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I’m a Cancer Patient. Should I Ask About PARP Inhibitors? - US News and World Report

Posted: 19 Jan 2010 11:17 AM PST

Deborah Armstrong, M.D.PARP stands for poly ADP-ribose polymerase, an enzyme found in the nucleus of cells that is responsible for repairing damage to DNA. While repairing DNA is critical to preventing the genetic mutations that give rise to cancer, many treatments for cancer actually aim to damage the DNA of the cancer cell. Many chemotherapy drugs used today directly or indirectly work by damaging DNA and do this more potently in cancer cells than in normal cells.

PARP inhibitors work by inactivating the PARP enzyme. There are at least eight PARP inhibitors in development, but none are yet approved by the Food and Drug Administration. PARP inhibitors have been of particular interest for patients who have a cancer that is associated with a BRCA mutation, such as those with familial breast or ovarian cancer. The BRCA proteins, important in one DNA repair pathway, are inactive in these BRCA-associated cancers. When a second DNA repair pathway is inactivated using a PARP inhibitor, BRCA-associated cancers show response rates that are significant and sometimes higher than would be expected with other available treatments.

In other studies, PARP inhibitors are used with chemotherapy agents whose toxicity is repaired by PARP in the cancer cell. Inhibiting PARP makes the cancer cell more susceptible to the chemotherapy. One of these is the drug temozolomide, used to treat certain brain tumors and melanoma. Other studies have used PARP inhibitors in combination with platinum agents, chemotherapy drugs used to treat a wide variety of cancers, such as ovarian, lung, and testicular cancers, among others. One highly publicized study showed a significant increase in the response of patients with "triple negative" breast cancer when chemotherapy was given with a PARP inhibitor. In triple-negative breast cancer, three treatment targets—the estrogen receptor, the progesterone receptor, and HER2/neu—are all absent.

If you are interested in PARP inhibitors, you should speak with your oncologist to see if you are eligible for any of the current trials.

 

Health Advice Disclaimer: The information provided on this website is for the general information of the reader and to help patients become better informed to consult with their own physician. It does not constitute a doctor-patient relationship, and it is not a substitute for professional medical advice. You should not use the information on this website for diagnosing or treating… Read more >>

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