plus 4, Estrogen Receptor-alpha may Increase Survival Benefit Among Breast ... - Med India |
- Estrogen Receptor-alpha may Increase Survival Benefit Among Breast ... - Med India
- A tone-deaf message on mammograms - Boston Globe
- Breast Cancer Campaign: Breast Cancer Research Funding to Establish ... - PR Inside
- Hormones Produced During Pregnancy Causes a Protein to Offset the ... - Med India
- Woman in breast cancer charade back in court - WTVF
| Estrogen Receptor-alpha may Increase Survival Benefit Among Breast ... - Med India Posted: 27 Nov 2009 07:33 AM PST Approximately 50% of breast carcinomas are resistant to tamoxifen. Preclinical studies have shown that ER-alpha S118-P is required for response to tamoxifen. Göran Landberg, M.D., Ph.D., of the Breakthrough Breast Cancer Research Unit, School of Cancer, Enabling Sciences and Technology at the University of Manchester, and colleagues evaluated data from 239 premenopausal patients with breast cancer who participated in a randomized trial of 2 years of adjuvant tamoxifen treatment vs. no systemic treatment. The association between recurrence-free survival and ER-alpha S118-P expression in tumor tissue was investigated. Researchers found evidence of a statistically significant recurrence-free survival benefit from adjuvant tamoxifen, compared with no systemic treatment, among patients whose tumors had high ER-alpha S118-P expression (23.7 vs. 72.2 recurrences per 1000 person-years) but not among patients whose tumors had low expression (51.0 vs. 57.0 recurrences per 1000 person-years). ER-alpha S118-P was not associated with a benefit among untreated patients. "Our study highlights the importance of assessing the functionality of a drug target," the authors write. "Future studies are necessary to evaluate whether ER-alpha S118-P expression is associated with tamoxifen response among post-menopausal patients."
Source-Eurekalert This content has passed through fivefilters.org.  This posting includes an audio/video/photo media file: Download Now |
| A tone-deaf message on mammograms - Boston Globe Posted: 27 Nov 2009 05:46 AM PST What the scientists did, says Carnegie Mellon's Baruch Fischhoff, who studies the fine art of risk communication, "is give an external view of what's true at the population level.'' In other words, they told the statistical story from up high. This content has passed through fivefilters.org. |
| Breast Cancer Campaign: Breast Cancer Research Funding to Establish ... - PR Inside Posted: 26 Nov 2009 02:12 AM PST 2009-11-26 11:14:04 -
Scientists are closer to discovering why some people respond to breast cancer radiotherapy better than others, according to Breast Cancer Campaign. Dr Laura Smith, at the Leeds Institute of Molecular Medicine, University of Leeds, has been awarded a pilot grant by Breast Cancer Campaign, to study why some types of breast cancers are difficult to destroy with radiotherapy. The grant forms part of £2 million awarded to 20 projects in the UK and Ireland.Previous research has shown that breast cancer cells which are difficult to destroy with radiotherapy contained reduced amounts of molecules called GRP78, PSMD9 and DARS. Dr Smith and her team aim to find out what role these molecules play in preventing radiotherapy from working in breast cancer. Dr Smith said, "We are grateful for this funding from Breast Cancer Campaign which we hope will lead to a way to predict how successful treatment will be in people with different types of breast cancer." The 2008 Research Assessment Exercise showed the University of Leeds to be the UK's eighth biggest research powerhouse. The University is one of the largest higher education institutions in the UK and a member of the Russell Group of research-intensive universities. The University's vision is to secure a place among the world's top 50 by 2015. www.leeds.ac.uk : This information was brought to you by Cision www.cisionwire.com : Breast Cancer CampaignClaire Learner, Media Relations Officer020 7749 3705email: clearner@breastcancercampaign.org : mailto:clearner@breastcancercampaign.org This content has passed through fivefilters.org.  This posting includes an audio/video/photo media file: Download Now |
| Hormones Produced During Pregnancy Causes a Protein to Offset the ... - Med India Posted: 27 Nov 2009 04:34 AM PST "Hormones in pregnancy, such as estrogen, all induce AFP, which directly inhibits the growth of breast cancer," said lead researcher Herbert Jacobson, Ph.D., who is a basic breast cancer researcher in the Center for Immunology and Microbial Diseases and in the Department of Obstetrics, Gynecology and Reproductive Sciences at Albany Medical College, N.Y. "The body has a natural defence system against breast cancer. "AFP needs to be safely harnessed and developed into a drug that can be used to protect women from breast cancer," he added. During the study, researchers sought to determine whether administering pregnancy hormones to carcinogen-exposed rats led them to produce AFP, which in turn produces the protective effect of pregnancy in the absence of pregnancy. They found that treatment with estrogen plus progesterone, estrogen alone or human chorionic gonadotropin reduced the incidence of mammary cancers in rats. Furthermore, the researchers noted that each of these treatments elevated the serum level of AFP and that AFP directly inhibited the growth of breast cancer cells growing in culture, suggesting that these hormones of pregnancy are preventing breast cancer through their induction of AFP. "The researchers have not directly demonstrated the cancer preventive activity of AFP, instead they found an association of these hormones preventing mammary tumors. None of these treatments prevented mammary tumors in 100 percent of the rats, it appears to delay mammary tumor formation and prevent breast cancer development in approximately 30 to 50 percent of the rats," Cancer Prevention Research Editorial Board Member Powel Brown, M.D., Ph.D.. This content has passed through fivefilters.org. |
| Woman in breast cancer charade back in court - WTVF Posted: 24 Nov 2009 03:29 PM PST Associated Press - November 24, 2009 6:35 PM ET CHATTANOOGA, Tenn. (AP) - A Chattanooga woman who lied about having breast cancer and took donations of sick leave, health services and cash has made a brief appearance in court. A prosecutor said during the hearing Tuesday that evidence gathering is continuing in the case of former city employee Keele Maynor. A judge ordered Maynor to return to court Jan. 5 for an update on the government's evidence gathering in the fraud case. Maynor resigned from her job as a city administrative assistant in December 2008, saying in an e-mail that her 5-year claim of having breast cancer was a charade. She is charged with theft and forgery. Her attorney, Stuart Brown, said prosecutors are trying to get records that show the amount of Maynor's financial benefit from the fraud. Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. This content has passed through fivefilters.org.  This posting includes an audio/video/photo media file: Download Now |
| You are subscribed to email updates from Add Images to any RSS Feed To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
No comments:
Post a Comment