“SIU doc gets big grant to study exercise, cancer - KFVS12” plus 4 more |
- SIU doc gets big grant to study exercise, cancer - KFVS12
- Side Effect Seen in Breast Cancer Drug - AOL
- Mentor Capital: A Stealth Cancer Immunotherapy Play - Seekingalpha.com
- Wedding gown sale to benefit breast cancer foundation - KSDK
- Small peptide found to stop lung cancer tumor growth in mice - EurekAlert
| SIU doc gets big grant to study exercise, cancer - KFVS12 Posted: 26 Aug 2009 08:29 AM PDT Associated Press - August 26, 2009 4:14 AM ET SPRINGFIELD, Ill. (AP) - A researcher at Southern Illinois University's medical school has received a big federal grant to study exercise and breast cancer. The $3.5 million grant is from the National Cancer Institute to cover the 5-year study. SIU's Dr. Laura Rogers is the principal investigator and an associate professor of internal medicine at the school in Springfield. She's long been interested in the effects of exercise on chronic disease. The new study will examine how a three-month exercise program affects breast cancer survivors, their quality of life, fatigue and joint function. Rogers works at SIU's SimmonsCooper Cancer Institute, which is focusing the medical school's efforts in cancer research, physician and public education, and treatment for patients from across central and southern Illinois. Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.  This posting includes an audio/video/photo media file: Download Now |
| Side Effect Seen in Breast Cancer Drug - AOL Posted: 26 Aug 2009 11:57 AM PDT PITTSONIT 03:38 PMAug 26 2009 I just found a new website www.who gives a crap.com , spam scam,just, go, away .org...  This posting includes an audio/video/photo media file: Download Now |
| Mentor Capital: A Stealth Cancer Immunotherapy Play - Seekingalpha.com Posted: 26 Aug 2009 11:57 AM PDT On 7/8/09, in the first of four steps leading to an anticipated merger and name change, Mentor Capital (MNTR.PK) acquired a 20% ownership stake in an innovative clinical stage cancer immunotherapy company, Quantum Immunologics, Inc. (QI). QI is a privately held company with a goal of initially marketing its active immunotherapy for the treatment of breast cancer in the U.S., in addition to planning for new studies in other types of cancer and a new cancer screening tool. Mentor Capital is providing funding for QI to complete its ongoing, FDA-authorized Phase I/II trials for its experimental metastatic breast cancer treatment, in addition to possible acquisitions and additional clinical trials. Currently, the 1,386 shareholders on Mentor Capital stock hold $145 million in stepped warrants that will provide a continual flow of equity to fund QI and other projects. Mentor Capital has $13.5 million in assets under management through its lead hedge fund's S&P 500 investment portfolio, which has generated a 31.4% annualized rate of return on MNTR.PK invested funds since inception last year compared to a flat 0% return for the Dow Jones Industrial Average in the same time frame, as previously announced on 5/27/09. In addition to providing $2.2 million in funding to help support the FDA Phase I/II trial through approximately February 2010, Mentor Capital has agreed to assist QI in funding future strategic stock or cash acquisitions. The Company will also serve as a preferred funding source for QI during later stage or additional trials. In exchange for this funding support, Mentor Capital has received common stock in QI reflecting a carried interest of 20%. At the current private placement price for the QI shares, this 20% stake in QI increases the assets of Mentor Capital by $3.74 per share. Mentor Capital has nearly completed its second year of financial audits, clearing the way to start the process of moving the stock off the Pink Sheets to become a fully-reporting entity on the OTCBB and eventually graduating to the AMEX or Nasdaq. As of year-end 2008, Mentor Capital had 221,742 average weighted common shares of stock outstanding and posted the following full-year financial results:
The Mentor Capital website also features a Cancer Immunotherapy (CI) Index of 10 stocks, which has posted a gain of about 23% since its inception six weeks ago on 7/10/09 to reflect the start of the Company's initial 20% stake in QI. The index currently features the following 10 component companies, in addition to Mentor Capital as a public-traded proxy for tracking QI: Dendreon (NASDAQ:DNDN), ImmunoCellular Therapeutics (IMUC.OB), Antigenics (NASDAQ:AGEN), Biovest (BVTI.PK), Celldex Therapeutics (NASDAQ:CLDX), Oncothyreon (NASDAQ:ONTY), Northwest Biotherapeutics (NWBO.OB), CEL-SCI Corp. (AMEX:CVM), and Generex Biotechnology (NASDAQ:GNBT) (as a proxy for its wholly-owned immunotherapeutic subsidiary, Antigen Express). The CI Index is primarily a subset of my actively managed Cancer Diagnostic & Therapeutic (Dx/Tx) Micro-Cap Index, which reflects a cross-section of emerging cancer companies with market caps below $250 million at the time of index inclusion. In addition, Mentor Capital expects to update the CI Index on a weekly basis at its website. Quantum's approach to cancer immunotherapy involves sensitizing the dendritic cells from a patient's own blood to recognize and direct the body's immune system to attack breast cancer sites in a targeted effort to eradicate or stabilize the disease. This approach does not involve breast surgery (e.g. complete or partial removal of breast tissue), chemotherapy, or radiation – with the goal of eliciting a targeted immune response directed at cancer cells which may prove to be more effective and safer (i.e. a few days of temporary flu-like symptoms following treatment as the immune system attacks the cancer cells) than existing treatments. Dendreon follows a similar approach for prostate cancer and has a market cap of about $2.7 billion as it prepares to become a commercial-stage company with the possible 2010 launch of Provenge (sipuleucel-T), following positive Phase 3 results announced earlier this year which demonstrated an acceptable safety profile and survival benefit beyond chemo that is expected to result in FDA approval for the treatment of metastatic, androgen-independent prostate cancer. Provenge is derived from a patient's own immune system (dendritic cells, hence the name Dendreon) and is poised (upon FDA approval) to become the first of a new class of therapeutics called active cellular immunotherapies ((ACI_) which are sometimes referred to as cancer vaccines (even though treatments such as Provenge are not designed to prevent the disease like Gardasil or Cervarix, which are designed to prevent HPV infection that is associated with cervical cancer). The dendritic cells are extracted from patients by a process called leukapheresis (a blood collection process which isolates white blood cells) and then attached to an antigen (a molecule or substance which elicits a reaction by the immune system) known as prostatic acid phosphatase (PAP), which is specific to prostate cancer cells and is not found elsewhere in the body. Dendritic cells are the primary antigen presenting cells (APCs) for the immune system which activate a T cell response against a given antigen. The patient's APCs are then transported to the Company's manufacturing facility where they are co-cultured with a recombinant fusion protein containing PAP. The activated, antigen-loaded APCs (which is Provenge) is then delivered to the physician's office for infusion into the patient with the goal of stimulating a T cell response targeted toward prostate cancer cells. The process is performed three times over the course of a four-week period, upon which treatment is completed. The FDA-authorized Phase I/II clinical trial for QI is described in full detail at the ClinicalTrials.gov website with the official title posted as, "Phase I/II Vaccine Study With Autologous Dendritic Cells Loaded With Oncofetal Antigen/iLRP (immature laminin receptor protein) in Patients With Metastatic Breast Cancer." The University of South Alabama serves as a collaborator while the trial is sponsored by QI with a ClinicalTrials.gov identifier of NCT00879489. The Phase I/II clinical trial is structured as an open label, single-arm, interventional treatment study designed to assess both efficacy and safety in a single, combined trial. Combining Phase I/II into a single study saves about six months and $1 million from the clinical development process for Mentor/QI and reflects optimism toward the prospects for the Company's experimental cancer immunotherapeutic. The study will be accomplished by collecting dendritic cells (APCs) from the each patient's blood using a machine to which the patient is connected through two small cannula placed into arm. The APCs will be manipulated in the lab with human recombinant oncofetal antigen (OFA/iLRP) and then injected into the skin of patients (intradermal administration). There will be a series of three monthly skin injections, administered at four-week intervals. The Company hopes to induce a safe, targeted anti-cancer response by this method and the outcome measures for the study will include toxicity/safety, response, survival, immunological monitoring, and time to disease progression. The OFA/iLRP patents are the by-product of 20 years and $30 million of research at The University of South Alabama Medical & Science Foundation and were primarily funded by the National Institute of Health's (NIH) National Cancer Institute (NCI). The study utilizes an antigen that is found only on cancer cells and is not detected on normal tissue. The molecule is known as oncofetal antigen or OFA because it is only found on cancer cells and early-stage fetal cells/embryos in the womb. Because OFA is unique to cancer, the Company believes OFA could be used to train the patients' own immune system to mount a targeted attack of cancer cells which express this antigen. Although OFA has been found in large concentrations on all cancer types, it was found to be especially abundant in breast cancers. A study published in a medical journal (Blood. 2003;102:4416-4423) stated that it has been documented in previous rodent and human studies that OFA-iLRP is an immunogenic protein that can specifically activate both T and B lymphocytes, making it an ideal antigen for immunotherapeutic strategies directed against all types of human cancer. The Phase I/II clinical trial is designed to examine the inherent immune response in breast cancer patients directed towards OFA/iLRP and whether this immune response could be amplified and modified through actively vaccinating using autologous (patient-derived) OFA/iLRP-pulsed dendritic cells which are re-injected into cancer patients. OFA/iLRP is the chosen target for this immunotherapy product candidate because it has been found to be expressed in all human cancers examined so far, including myeloid + lymphoid leukemias, lymphomas, renal cell (kidney) carcinomas, prostate cancer, breast cancer, lung cancer, melanoma, squamous cell carcinoma, and ovarian cancer. Furthermore, OFA/iLRP is not found in normal human tissue after mid-gestation during early fetal development. OFA/iLRP is not only a highly-specific tumor marker, but it is also immunogenic in humans (i.e. eliciting a response by the immune system) based on studies outlined at QI's website. By producing dendritic cells which are personalized from each breast cancer patient's blood monocytes, loading them with OFA/iLRP, and inducing their maturation with cytokines, QI produces an OFA/iLRP-specific autologous cellular therapy for the treatment of metastatic breast carcinoma. The mechanism of action of this active cancer immunotherapy product candidate is to generate a targeted and personalized immune T cell response that will fight the patient's cancer. The OFA/iLRP-loaded mature, moDCs (monocyte-derived dendritic cells) do not have a direct cytotoxic effect as with traditional treatments such as radiation therapy or chemo. Rather, the anti-cancer effect is generated by the presentation of OFA/iLRP to activate each patient's T cells for a targeted immune response to OFA/iLRP, which is specific to the patient's cancer cells which express this marker. This mode of action is distinct from chemotherapy, which kills not only tumor cells, but also affects normal cells such as those which divide rapidly (e.g. hair, GI tract, etc.). This approach is also different from immune-therapies that generically stimulate the immune system (e.g. cytokines such as Interleukin-2 or IL-2) or specifically target the tumor via an anti-tumor antibody (Herceptin- trastuzumab). Because the product requires the development of an immune response after administration, there is some delay in the potential effect of the product with the generation of each patient's immune response and a clinical effect of that may take several weeks to develop, and is typically characterized by transient, flu-like symptoms rather than the harsh side effects of radiation and/or chemotherapy. On 7/15/09, Mentor Capital announced that QI met a significant milestone which marked the beginning of its Phase I/II breast cancer trial upon the completion of the first clinical treatment injection. The Phase I/II clinical trial is testing the safety and efficacy of QI's immunotherapy on 27 Stage IV breast cancer patients who have failed conventional therapy, and the Company expects to provide updates on the study as it progresses. Mentor Capital's CEO, Chet Billingsley, stated that,
With expected updates and news flow from the ongoing Phase I/II clinical trial, Mentor Capital offers investors an under-the-radar opportunity for a promising new cancer immunotherapy approach which could apply to all types of cancer since OFA is only expressed on cancer cells and in early-stage fetal/embryonic development. At the current private placement price for the QI shares, Mentor Capital's 20% stake in QI increases the assets of the Company by $3.74/share, which is more than 2X the current stock price of $1.80/share. The prospects for this study and Mentor Capital are excellent since QI was given the okay for a combined Phase I/II trial, the study targets a cancer-specific marker (OFA/iLRP), the patents represent the by-product of two decades + $30 million of research that was primarily funded by NIH/NCI, and the previously announced positive Phase 3 results + potential 2010 launch of Provenge by Dendreon heightens investor awareness of the entire cancer immunotherapy space. Below is a Q+A session that I conducted for BioMedReports.com (BMR) earlier this week with Mentor Capital's CEO, Chet Billingsley (CB), to provide an update on the Company's stock and the expected timeline for clinical data catalysts from QI's ongoing Phase I/II study. Click here to visit Mentor Capital's page on Facebook.
Disclosure: Long MNTR.PK  This posting includes an audio/video/photo media file: Download Now |
| Wedding gown sale to benefit breast cancer foundation - KSDK Posted: 26 Aug 2009 11:49 AM PDT KSDK -- The Brides Against Breast Cancer national tour of gowns will be in St. Louis Friday and Saturday. St. Louis brides-to-be can get wedding gowns for a discounted price and help a good cause. The event will be at the Doubletree Hotel and Conference Center at 16625 Swingley Ridge Road in Chesterfield. For $20 you can go to the power hours from 10:00 a.m. until noon to get a preview of the dresses. Admission is free on Friday from noon to 8:00 p.m. and on Saturday from 10:00 a.m. to 6:00 p.m. Proceeds from the sale will go to the Making Memories Breast Cancer Foundation. Mary Helen McAnarney, the president of the foundation, joined NewsChannel 5's Jennifer Blome to talk about the sale. For more information about the foundation, go to http://www.makingmemories.org/ or call 5003-491-8091. For more information about the sale, go to http://bridesagainstbreastcancer.org/. KSDKThis posting includes an audio/video/photo media file: Download Now |
| Small peptide found to stop lung cancer tumor growth in mice - EurekAlert Posted: 26 Aug 2009 11:49 AM PDT ![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small} Public release date: 26-Aug-2009[ | E-mail |  Share ] Contact: Jessica Guenzel WINSTON-SALEM, N.C. In new animal research done by investigators at Wake Forest University School of Medicine, scientists have discovered a treatment effective in mice at blocking the growth and shrinking the size of lung cancer tumors, one of the leading causes of cancer death in the world. The study, recently published in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, is the first to show that treatment with a specific peptide, angiotensin-(1-7), reduces lung tumor growth by inhibiting blood vessel formation. "If you're diagnosed with lung cancer today, you've got a 15 percent chance of surviving five years and that's just devastating," said co-lead investigator Patricia E. Gallagher, Ph.D., director of the Molecular Biology Core Laboratory in the Hypertension and Vascular Research Center at the School of Medicine. "Those other 85 people 85 percent they're not going to see their kids graduate. They're not going to see their children get married." The lung cancer survival rate has changed little in the past 30 years, said Gallagher's co-lead investigator, E. Ann Tallant, Ph.D., a professor in the Hypertension and Vascular Research Center a fact that motivates them in their research. Peptides, found in all animals, are compounds formed by linking one or more amino acids together through the sharing of electrons. They are among the building blocks of life. Peptides can perform a wide range of functions in the body, depending on which amino acids are involved. Some can regulate hormones, for example, while others can have an antibiotic function. Angiotensin-(1-7) is a small peptide that binds to proteins on the surface of cells and prevents cell growth but only if the cell is actively growing when the binding occurs. That property is what led Tallant and Gallagher to explore the peptide's uses for treating cancer by blocking tumor growth. Angiotensin-(1-7) works by inhibiting the production of signals sent out by a cancer tumor for food. For tumors to grow, they need nutrients delivered by blood vessels. The signals they send prompt blood vessels to grow and invade the tumor to feed it. Every day during the six-week study, researchers injected either saline or the angiotensin (1-7) peptide into mice growing human lung cancer tumors. Over the course of the study, the tumors treated with angiotensin-(1-7) shrunk, while the saline-treated tumors grew and, at the end of the study, the tumors treated with angiotensin-(1-7) weighed about 60 percent less than the tumors treated with saline. Analysis also showed that the tumors from mice treated with the peptide had significantly fewer blood vessels compared to the tumors from the saline-treated animals. The researchers further tested angiotensin (1-7)'s affect on blood vessel formation, or angiogenesis, by treating chick embryos with the peptide a procedure considered the gold standard for determining anti-angiogenic ability. They found that blood vessels continued to grow in a saline-injected control group, while blood vessel formation decreased by more than 50 percent in the embryos treated with angiotensin-(1-7). Tallant and Gallagher said the treatment likely has applications beyond lung cancer they have collected data showing it is effective on breast, colon and brain tumors, as well. The treatment also presents an attractive possibility for future human cancer therapy from a cost perspective, they said. "Because it's a peptide, it's very small and can be made very easily," Gallagher said. "We sometimes like to say we're the aspirin of cancer therapy."
Co-investigators on the study were graduate students David R. Soto-Pantoja and Jyotsana Menon of the School of Medicine. The study was funded by the Susan G. Komen Breast Cancer Research Foundation, Department of Defense, National Institutes of Health, Unifi, Farley-Hudson Foundation, and Golfers Against Cancer of the Triad. The first clinical trial of angiotensin-(1-7) has been completed at the School of Medicine and the results are currently being reviewed. Media Relations Contacts: Jessica Guenzel, jguenzel@wfubmc.edu, (336) 716-3487; Bonnie Davis, bdavis@wfubmc.edu, (336) 716-4977; or Shannon Koontz, shkoontz@wfubmc.edu, (336) 716-2415. Wake Forest University Baptist Medical Center (www.wfubmc.edu) is an academic health system comprised of North Carolina Baptist Hospital, Brenner Children's Hospital, Wake Forest University Physicians, and Wake Forest University Health Sciences, which operates the university's School of Medicine and Piedmont Triad Research Park. The system comprises 1,056 acute care, rehabilitation and long-term care beds and has been ranked as one of "America's Best Hospitals" by U.S. News & World Report since 1993. Wake Forest Baptist is ranked 32nd in the nation by America's Top Doctors for the number of its doctors considered best by their peers. The institution ranks in the top third in funding by the National Institutes of Health and fourth in the Southeast in revenues from its licensed intellectual property. [ | E-mail | Share ]
 This posting includes an audio/video/photo media file: Download Now |
| You are subscribed to email updates from Add Images to any RSS Feed To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
No comments:
Post a Comment